CCR7

CCR7
CCR7
Идентификаторы
Символ	CCR7 ; BLR2; CD197; CDw197; CMKBR7; EBI1
Внешние ID	OMIM: 600242 MGI: 103011 HomoloGene: 1387 IUPHAR: CCR7 ChEMBL: 4594 GeneCards: Ген CCR7
Функция	• G-protein coupled receptor activity; • C-C chemokine receptor activity; • chemokine (C-C motif) ligand 19 binding; • chemokine (C-C motif) ligand 21 binding; • C-C motif chemokine 19 receptor activity; • C-C motif chemokine 21 receptor activity;
Компонент клетки	• intracellular; • plasma membrane; • external side of plasma membrane; • integral component of membrane;
Биологический процесс	• establishment of T cell polarity; • positive regulation of cell-matrix adhesion; • dendritic cell chemotaxis; • myeloid dendritic cell chemotaxis; • positive regulation of dendritic cell antigen processing and presentation; • positive regulation of hypersensitivity; • positive regulation of humoral immune response; • inflammatory response; • immune response; • G-protein coupled receptor signaling pathway; • positive regulation of cytosolic calcium ion concentration; • positive regulation of actin filament polymerization; • positive regulation of pseudopodium assembly; • ruffle organization; • response to lipopolysaccharide; • regulation of interferon-gamma production; • positive regulation of interleukin-12 production; • activation of Rho GTPase activity; • response to prostaglandin E; • chemokine (C-C motif) ligand 19 signaling pathway; • chemokine (C-C motif) ligand 21 signaling pathway; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of phosphatidylinositol 3-kinase activity; • negative thymic T cell selection; • positive regulation of cell adhesion; • positive regulation of protein kinase activity; • positive regulation of JNK cascade; • regulation of interleukin-1 beta secretion; • positive regulation of T cell receptor signaling pathway; • release of sequestered calcium ion into cytosol; • positive regulation of filopodium assembly; • positive regulation of protein kinase B signaling; • chemokine-mediated signaling pathway; • positive regulation of ERK1 and ERK2 cascade; • cellular response to cytokine stimulus; • response to nitric oxide; • interleukin-12 secretion; • positive regulation of neutrophil chemotaxis; • lymphocyte migration into lymph node; • mature dendritic cell differentiation; • negative regulation of leukocyte apoptotic process; • positive regulation of cell motility; • positive regulation of dendritic cell chemotaxis; • positive regulation of immunological synapse formation; • positive regulation of T cell costimulation; • positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation; • regulation of dendritic cell dendrite assembly;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
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Ортологи

CCR7 (C-C-рецептор хемокина 7, англ. C-C chemokine receptor type 7) — рецептор β-хемокинов млекопитающих класса интегральных мембранных белков. CCR7 является рецептором для двух лигандов: хемокинов CCL19 и CCL21.^[1] Продукт гена CCR7.

Функции

Белок CCR7 входит в семейство рецепторов, сопряжённых с G-белком. Он был первоначально идентифицирован как ген, индуцируемый вирусом Эпштейна — Барр и считался медиатором эффекта вируса на B-лимфоциты. CCR7 экспрессирован на клетках различных лимфоидных тканей и активирует B- и T-лимфоциты. Рецептор контролирует миграцию Т-клеток памяти во вторичные лимфоидные органы, такие как лимфатические узлы, а также стимулирует созревание дендритных клеток.

Клиническое значение

CCR7 представлен на различных раковых клетках, таких как немелкоклеточный рак лёгкого, рак желудка и рак пищевода.^[2]^[3]^[4] Экспрессия CCR7 на раковых клетках связана с их метастазировением в лимфатические узлы.^[5]

Примечания

↑ F. Balkwill, Cancer and the Chemokine Network, Nature reviews, 2004
↑ Mashino, K. et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res. 62, 2937–2941 (2002)
↑ Takanami, I. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. Int. J. Cancer 105, 186–189 (2003)
↑ Ding, Y. et al. Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. Clin. Cancer Res. 9, 3406–3412 (2003)
↑ Shields J.D., Fleury M.E., Yong C., Tomei A.A., Randolph G.J., Swartz M.A. Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling (англ.) // Cancer Cell : journal. — 2007. — June (vol. 11, no. 6). — P. 526—538. — doi:10.1016/j.ccr.2007.04.020. — PMID 17560334.

Библиография

Müller G., Lipp M. Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking. (англ.) // Microcirculation (New York, N.Y. : 1994) : journal. — 2003. — Vol. 10, no. 3—4. — P. 325—334. — doi:10.1038/sj.mn.7800197. — PMID 12851649.
Burgstahler R., Kempkes B., Steube K., Lipp M. Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2 (англ.) // Biochemical and Biophysical Research Communications^[англ.] : journal. — 1995. — Vol. 215, no. 2. — P. 737—743. — doi:10.1006/bbrc.1995.2525. — PMID 7488016.
Schweickart V.L., Raport C.J., Godiska R., et al. Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2 (англ.) // Genomics : journal. — Academic Press, 1995. — Vol. 23, no. 3. — P. 643—650. — doi:10.1006/geno.1994.1553. — PMID 7851893.

Ссылки

База данных IUPHAR Database of Receptors and Ion Channels. Международный союз фундаментальной и клинической фармакологии.

[1] F. Balkwill, Cancer and the Chemokine Network, Nature reviews, 2004

[2] Mashino, K. et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res. 62, 2937–2941 (2002)

[3] Takanami, I. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. Int. J. Cancer 105, 186–189 (2003)

[4] Ding, Y. et al. Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. Clin. Cancer Res. 9, 3406–3412 (2003)

[pmid17560334-5] Shields J.D., Fleury M.E., Yong C., Tomei A.A., Randolph G.J., Swartz M.A. Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling (англ.) // Cancer Cell : journal. — 2007. — June (vol. 11, no. 6). — P. 526—538. — doi:10.1016/j.ccr.2007.04.020. — PMID 17560334.

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