Трансформирующий ростовой фактор, бета-1

Трансформирующий ростовой фактор, бета-1 (ТРФбета-1) — белок человека, являющийся первым описанным членом семейства ТРФ-бета, которое, в свою очередь, является частью обширного суперсемейства ТРФ-бета. Ген TGFB1, кодирующий данный белок, находится у человека на 19-й хромосоме.

Трансформирующий ростовой фактор, бета-1
Доступные структуры PDB Поиск ортологов: PDBe RCSB Список идентификаторов PDB 1KLA, 1KLC, 1KLD, 3KFD, 4KV5
Идентификаторы
Псевдонимы	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta, transforming growth factor beta 1, IBDIMDE, TGF-beta1
Внешние ID	OMIM: 190180 MGI: 98725 HomoloGene: 540 GeneCards: TGFB1
Расположение гена (человек) Хр. 19-я хромосома человека Локус 19q13.2 Начало 41,301,587 bp Конец 41,353,922 bp
Расположение гена (Мышь) Хр. 7-я хромосома мыши Локус 7 A3|7 13.98 cM Начало 25,386,427 bp Конец 25,404,502 bp
Паттерн экспрессии РНК Bgee Человек Мышь (ортолог) Наибольшая экспрессия в stromal cell of endometrium Descending thoracic aorta Наибольшая экспрессия в tibiofemoral joint stroma of bone marrow lower jaw body of femur Дополнительные справочные данные BioGPS Дополнительные справочные данные
Генная онтология Молекулярная функция type II transforming growth factor beta receptor binding protein N-terminus binding cytokine activity enzyme binding growth factor activity antigen binding type I transforming growth factor beta receptor binding гомодимеризация белка protein serine/threonine kinase activator activity связывание с белками плазмы protein heterodimerization activity type III transforming growth factor beta receptor binding transforming growth factor beta receptor binding связывание похожих белков Компонент клетки цитоплазма внеклеточная область клеточное ядро Микроворсинка поверхность клетки blood microparticle клеточная мембрана secretory granule аксон soma Люмен аппарата Гольджи platelet alpha granule lumen внеклеточный матрикс внеклеточное пространство Биологический процесс positive regulation of histone deacetylation positive regulation of transcription regulatory region DNA binding ureteric bud development tolerance induction to self antigen positive regulation of protein phosphorylation endoderm development response to cholesterol positive regulation of MAP kinase activity regulation of sodium ion transport response to progesterone negative regulation of cell cycle response to organic substance развитие молочных желёз T cell homeostasis negative regulation of ossification negative regulation of hyaluronan biosynthetic process фосфорилация белка T cell differentiation positive regulation of vascular permeability регенерация органов positive regulation of blood vessel endothelial cell migration negative regulation of epithelial cell proliferation regulation of binding inner ear development myelination negative regulation of macrophage cytokine production пролиферация transforming growth factor beta receptor signaling pathway face morphogenesis негативная регуляция пролиферации клеток positive regulation of receptor clustering regulation of apoptotic process positive regulation of collagen biosynthetic process cellular response to transforming growth factor beta stimulus pathway-restricted SMAD protein phosphorylation regulation of DNA binding regulation of actin cytoskeleton reorganization negative regulation of fat cell differentiation positive regulation of protein metabolic process cell-cell junction organization negative regulation of myoblast differentiation позитивная регуляция сигналов от протеинкиназы В common-partner SMAD protein phosphorylation positive regulation of branching involved in ureteric bud morphogenesis SMAD protein signal transduction epidermal growth factor receptor signaling pathway macrophage derived foam cell differentiation negative regulation of blood vessel endothelial cell migration positive regulation of protein dephosphorylation extrinsic apoptotic signaling pathway negative regulation of extracellular matrix disassembly mitotic cell cycle checkpoint signaling positive regulation of fibroblast proliferation negative regulation of cell differentiation regulation of branching involved in mammary gland duct morphogenesis positive regulation of exit from mitosis negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of gene expression morphogenesis of a branching structure regulation of SMAD protein signal transduction positive regulation of peptidyl-serine phosphorylation cell activation negative regulation of neuroblast proliferation ДНК-зависимая позитивная регуляция транскрипции пролиферация negative regulation of T cell proliferation response to wounding negative regulation of cell growth positive regulation of chemotaxis protein export from nucleus regulation of protein import into nucleus positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein import into nucleus positive regulation of cardiac muscle cell differentiation oligodendrocyte development positive regulation of interleukin-17 production воспалительная реакция negative regulation of interleukin-17 production развитие лимфатического узла T cell activation Notch signaling pathway negative regulation of protein phosphorylation regulation of blood vessel remodeling SMAD protein complex assembly regulation of striated muscle tissue development response to vitamin D chondrocyte differentiation regulatory T cell differentiation regulation of cartilage development branch elongation involved in mammary gland duct branching positive regulation of bone mineralization positive regulation of epithelial cell proliferation женская беременность cellular response to organic cyclic compound positive regulation of extracellular matrix assembly cellular calcium ion homeostasis Заживление ран negative regulation of transcription by RNA polymerase II response to glucose positive regulation of epithelial to mesenchymal transition cellular response to dexamethasone stimulus negative regulation of production of miRNAs involved in gene silencing by miRNA mitigation of host defenses by virus lens fiber cell differentiation positive regulation of NF-kappaB transcription factor activity extracellular matrix assembly ATP biosynthetic process hematopoietic progenitor cell differentiation regulation of interleukin-23 production positive regulation of protein secretion frontal suture morphogenesis Эпителиально-мезенхимальный переход phosphate-containing compound metabolic process Регуляция экспрессии генов adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of release of sequestered calcium ion into cytosol response to radiation mononuclear cell proliferation negative regulation of transcription, DNA-templated negative regulation of T cell activation positive regulation of odontogenesis lipopolysaccharide-mediated signaling pathway positive regulation of protein localization to nucleus response to estradiol regulation of cell migration response to hypoxia hyaluronan catabolic process negative regulation of phagocytosis response to organic cyclic compound positive regulation of protein-containing complex assembly protein kinase B signaling negative regulation of cell-cell adhesion negative regulation of gene silencing by miRNA positive regulation of regulatory T cell differentiation cellular response to growth factor stimulus positive regulation of pathway-restricted SMAD protein phosphorylation mammary gland branching involved in thelarche response to laminar fluid shear stress старение человека regulation of regulatory T cell differentiation platelet degranulation negative regulation of DNA replication myeloid dendritic cell differentiation salivary gland morphogenesis receptor catabolic process MAPK cascade positive regulation of histone acetylation regulation of transforming growth factor beta receptor signaling pathway positive regulation of phosphatidylinositol 3-kinase activity negative regulation of protein localization to plasma membrane positive regulation of NAD+ ADP-ribosyltransferase activity negative regulation of immune response regulation of cell population proliferation negative regulation of skeletal muscle tissue development positive regulation of peptidyl-threonine phosphorylation positive regulation of smooth muscle cell differentiation positive regulation of isotype switching to IgA isotypes connective tissue replacement involved in inflammatory response wound healing ossification involved in bone remodeling positive regulation of apoptotic process positive regulation of vascular endothelial growth factor production positive regulation of superoxide anion generation digestive tract development миграция клеток positive regulation of fibroblast migration positive regulation of cell division germ cell migration положительная регуляция транскрипции РНК полимеразой II промотор negative regulation of mitotic cell cycle positive regulation of SMAD protein signal transduction positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of gene expression позитивная регуляция пролиферации клеток регенерация печени regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of mononuclear cell migration cellular response to insulin-like growth factor stimulus positive regulation of cell migration response to immobilization stress cellular response to mechanical stimulus cellular response to ionizing radiation васкулогенез neural tube closure heart valve morphogenesis развитие сердца развитие нервной трубки membrane protein intracellular domain proteolysis leukocyte migration ventricular cardiac muscle tissue morphogenesis positive regulation of ERK1 and ERK2 cascade transforming growth factor beta receptor signaling pathway involved in heart development embryonic liver development BMP signaling pathway развитие клеток апоптоз regulation of pri-miRNA transcription by RNA polymerase II positive regulation of production of miRNAs involved in gene silencing by miRNA regulation of signaling receptor activity Источники: Amigo, QuickGO
Ортологи Вид Человек Мышь Entrez 7040 21803 Ensembl ENSG00000105329 ENSMUSG00000002603 UniProt P01137 P04202 RefSeq (мРНК) NM_000660 NM_011577 RefSeq (белок) NP_000651 NP_035707 Локус (UCSC) Chr 19: 41.3 – 41.35 Mb Chr 7: 25.39 – 25.4 Mb Поиск по PubMed Искать Искать
Информация в Викиданных
Смотреть (человек) Смотреть (мышь)

Клиническое значение

Мутации TGFB1 вызывают болезнь Камурати-Энгельманна I типа (OMIM 131300).

См. также

• Трансформирующий ростовой фактор, бета-2
• Трансформирующий ростовой фактор, бета-3
• TGFBI — «TGF-β-индуцируемый белок»

Ссылки

• TGF-бета1 (трансформирующий фактор роста бета1) — medbiol.ru
• TGFb (трансформирующий ростовой фактор-бета, ТРФ-бета) — medbiol.ru